Effect of mevalonate analogues upon cholesterol biosynthesis

Effect of mevalonate analogues upon cholesterol biosynthesis

Three analogues of mevalonic acid have been found to inhibit cholesterol biosynthesis in liver homogenates in the following order of efficacy: 3-methyl-3-hydroxy pentanoic acid > A*3methyl pentenoic acid > As-3-methyl pentenoic acid. The hydroxy acid produces half the maximum inhibition at a concentration of 5 pmoles/ml of homogenate. This corresponds to a ratio of 100 pmoles of inhibitor to 1 ...

Cholesterol Biosynthesis: Mevalonate Synthesis Inhibited by Bile Salts.

Certain bile salts inhibit biosynthesis of mevalonate from acetate-2-C(14) in normal rat liver homogenates. The physiological control of cholesterol biosynthesis is discussed.

Regulation of isoprenoid/cholesterol biosynthesis in cells from mevalonate kinase-deficient patients.

Mevalonic aciduria (MA) and hyper-IgD and periodic fever syndrome (HIDS) are two inherited disorders both caused by depressed mevalonate kinase (MK) activity. MK is the first enzyme to follow the highly regulated 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase (HMGR), which catalyzes the rate-limiting step in the isoprenoid/cholesterol biosynthesis pathway. In fibroblasts of MA patients, but not...

Five Questions about Non-Mevalonate Isoprenoid Biosynthesis

Isoprenoids (also referred to as terpenoids) are the largest group of natural products, comprising over 25,000 known compounds [1]. Each member of this class is assembled from 5-carbon (C5) isoprene units and derived metabolically from the basic building block isopentenyl pyrophosphate (IPP) and its isomer, dimethylallyl pyrophosphate (DMAPP). Subsequent metabolic reactions (such as cyclization...

Biosynthesis of Cholesterol